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Fair Generalized Linear Models with a Convex Penalty
Despite recent advances in algorithmic fairness, methodologies for achieving fairness with generalized linear models (GLMs) have yet to …
Hyungrok Do, Preston Putzel, Axel S. Martin, Padhraic Smyth, Judy Zhong
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Harnessing Clinical Sequencing Data for Survival Stratification of Patients With Metastatic Lung Adenocarcinomas
By using sequencing results from a cohort of 1,054 patients with advanced lung adenocarcinomas, we developed OncoCast, a machine learning tool for survival risk stratification and biomarker identification. We found that comutations of both STK11 and KEAP1 are strong determinants of unfavorable prognosis with currently available therapies.
Ronglai Shen, Axel S. Martin, Ai Ni, Matthew Hellmann, Kathryn C. Arbour, Emmet Jordan, Arshi Arora, Ryan Ptashkin, Ahmet Zehir, Mark G. Kris, Charles M. Rudin, Michael F. Berger, David B. Solit, Venkatraman E. Seshan, Maria Arcila, Marc Ladanyi, Gregory J. Riely
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Harnessing Clinical Sequencing Data for Survival Stratification of Patients With Metastatic Lung Adenocarcinomas
Genetic variants and cognitive functions in patients with brain tumors
This novel study suggests that polymorphisms in genes involved in aging and inflammation, dopamine, myelin and cell cycle regulation, and DNA repair and response to oxidative stress may be associated with cognitive outcome in patients with brain tumors.
Denise D Correa, Jaya Satagopan, Axel S. Martin, Erica Braun, Maria Kryza-Lacombe, Kenneth Cheung, Ajay Sharma, Sofia Dimitriadoy, Kelli O’Connell, Siok Leong, Sasan Karimi, John Lyo, Lisa M DeAngelis, Irene Orlow
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Analysis of the canid Y-chromosome phylogeny using short-read sequencing data reveals the presence of distinct haplogroups among Neolithic European dogs
Utilizing a recently published dog Y-chromosome reference, we analyzed Y-chromosome sequence across a diverse collection of canids and determined the Y haplogroup of three ancient European dogs. We estimate that the time to the most recent comment ancestor of dog Y haplogroups is 68–151 thousand years ago and confirm long-standing population structure among European dogs.
Matthew T. Oetjens, Axel S. Martin, Krishna R. Veeramah, Jeffrey M. Kidd
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Analysis of the canid Y-chromosome phylogeny using short-read sequencing data reveals the presence of distinct haplogroups among Neolithic European dogs